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This oxidation often induces conformational modifications of the protein because cysteine disulfide increases side-chain volume in the proteins interior and leads to unfavorable van der Waals interactions that maintain the original structure (13)

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It is thus likely that this is a major form of metal accumulation throughout the human life and that the ability of nano-sized crystals to generate reactive chemical species under irradiation with light may possibly be related to their activity as catalytic generators of free radicals when embedded into the living tissue