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The two main sources of intracellular Fe 2 + accumulation during ferroptosis are: (1) TF binds to TFR and enters the cell, where the low pH value promotes the release of Fe3 + from TF, which is then reduced to Fe 2 + in the cytoplasm
U.EsterbauerH.et al (1989)
Mice not treated with vitamin A, but receiving saline in the same dosage at the same time, were used as controls
The living cells were stained with 500 nM TPE-DCV for 5 min
Such inhibitors could be combined with mTOR inhibitors to finely modulate autophagy flux
Bibcode:2009Small...5..701A
