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The mechanism involves nanoparticles targeting the BBB to either induce or inhibit P-gp, resulting in reduced P-gp expression

Jastreboff AM, Kaplan LM, Frias JP, et al

Coupling The glutathione cycle is metabolically coupled to broader cellular energy biology Because the glutathione cycle depends on NADPH, and NADPH comes from glucose metabolism via the pentose phosphate pathway, the cycle is metabolically coupled to the broader cellular state

Furthermore, cytotoxicity on a normal cell line and antioxidant assay results were established

Then, a fermentation experiment in Erlenmeyer flasks was performed using the G3-SF strain (containing Sc GSH1, Sc GSH2, St GshF, and Sc ADK1), with the highest GSH titer and yield of 999.33 47.26 mg/L and 91.53 4.70 mg/g, respectively

[DOI] [PubMed] [Google Scholar] 92.Qiu S.X., Yang R.Z., Gross M.L