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Any haziness developed after initial reconstitution signals bacterial growth or peptide aggregation, both of which make the solution unusable

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It highlights the pressing need for both the discovery of novel antibacterial agents and innovative strategies, such as synergistic combinations to restore the efficacy of existing antibiotics, to curb the spread of these formidable drug-resistant infections (Jesudason, 2024)

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Future research should build on this framework by prioritizing well-powered, longitudinal, and mechanistically integrated study designs that combine precise cycle phase verification with multi-omics approaches (e.g., metabolomics, transcriptomics, and microbiome profiling)