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After metabolic activation, benzo[a]pyrene produces reactive intermediates that form DNA adducts, leading to damage that can result in gene mutations and initiate cancer development (Moore et al., 1982

Advanced experimental models, including patient-derived intestinal organoids, high-resolution copper imaging techniques, and detailed dissection of copper-mitochondriaautophagy interactions, will be required before intestine-targeted therapeutic strategies can be rationally integrated into WD management

TDP-43 skeins show properties of amyloid in a subset of ALS cases

Mice were housed in a standard laboratory animal facility under a 12-h light-dark cycle with free access to standard chow food and water

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Lacy JN, Ulirsch JC, Grace RF, et al