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In contrast, the goal of clinical periodontitis therapy is to achieve effective regeneration through a minimally invasive, non-surgical approach

Prednisone must be used before (0.5 mg/kg, every 12 h, for 2 days) and after (0.5 mg per kg every 24 h, for 3 days) the application, in addition to the use of promethazine (0.51.0 mg per kg every 12 h for 7 days)

antimutagenic effects in lymphocytes Each of these domains plays a foundational role in biological aging, and Epitalons ability to modulate them suggests its legitimate potential as a systemic geroprotector

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Future challenges are also discussed, including the identification of additional missing genetic causes of SLOCA, especially via the use of long-read genome sequencing, improvements in SLOCA prognostication and the implementation of clinical trials of neuroprotective interventions