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The HGF/c-Met pathway activated by Dihexa promotes neurite extension, axonal growth, and formation of both pre-synaptic terminals and post-synaptic densities essential for functional neural communication

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Apart from increased intracellular iron load, ferroptosis is also characterized by excessive lipid peroxidation and reduced expression and function of antioxidant defense genes, particularly glutathione peroxidase 4 (Gpx4) and system Xc(Xct) [11]

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In contrast to Trx1, incubation of Grx1 with 0.5 mM MQ resulted in 4 adducts and 1 mM MQ was needed for modification of all 5 thiols (Supplementary Fig