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Compromised p53 function, such as through mutation, abrogates its regulatory control over BNIP3 and NIX

doi: 10.1016/j.jtemb.2016.05.005

P 2.0 mg dl 1 was present in 36.4% of patients in the overweight BMI category, with a progressive increase to 43.3%, 57.3% and 72.0% for patients in the class I, II and III obesity categories, respectively

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Beyond direct H 2 O 2 scavenging, GSH also detoxifies lipid peroxidation byproducts, including malondialdehyde (MDA) and 4-HNE, through GST-mediated conjugation, facilitating their removal and preventing secondary cytotoxic signaling 91,92