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Broader metabolic coverage Metabolic syndrome involves multiple interconnected dysfunctions: insulin resistance, dyslipidemia, hypertension, visceral obesity, and chronic inflammation

This interaction creates a positive feedback loop where M2 macrophages, in turn, further enhance CSC survival, resistance to therapy, and tumor aggressiveness, making the CSCTAM crosstalk a significant target for potential therapeutic strategies (127)

[125] Norrish AE, Skeaff CM, Arribas GL, et al

doi: 10.1111/1523-1747.ep12492589

Bezafibrate inhibits HMG-CoA reductase activity in incubated blood mononuclear cells from normal subjects and patients with heterozygous familial hypercholesterolaemia

10.3389/fmed.2020.00154 95