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Around 30% of patients start with bulbar symptoms, which affect the muscles used for speaking and swallowing, leading to problems like slurred speech (dysarthria), trouble swallowing (dysphagia), and twitching of the tongue muscles (Chi et al., 2013)

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Importantly, and pointing toward oxidative stress as a mechanism implicated in hyperglycemia-induced glycocalyx degradation, the reduction in glycocalyx volume was largely prevented by treatment with an antioxidant agent (214)

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