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NPCs senescence may gradually accelerate the loss of Acan and type II collagen (Col-2), which weakens the tolerance of NP tissues to mechanical loading, causing disorders such as spinal instability and neurogenic pain [12]

10.1016/0090-6980(92)90137-I

These include chronic pain, frequent Tylenol use, drinking alcohol regularly, medication interactions, or a history of liver issues

Gong L-J, Wang X-Y, Gu W-Y, Wu X

Ph Li, Tp

doi: 10.1016/j.cell.2017.05.034
