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[DOI] [Google Scholar] Sendra JM, Sentandreu E, Navarro JL

10.1016/j.cell.2025.11.036 33 ClarkeS

Exposure to triggers such as free radicals induces the translocation of NRF2 into the nucleus, where it promotes the upregulation of antioxidant proteins and plays a defensive role against oxidative damage [210]

Despite these obstacles, the potential in this area is immense, and further exploration is warranted

In a systematic review and meta-analysis (17 studies, n=1342) including seven NP conditions, only third-tier evidence (obtained from well-designed controlled trials without randomization) was available, and only 2 trials determined amitriptyline was more efficacious than placebo