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Kinowaki, Y

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Plants have been studied for their therapeutic properties and they are also cheap, easily accessible and safer than synthetic conventional drugs ( Moringa oleifera has been proven in a number of studies to alleviate insulin resistance by activating the insulin-independent pathway PI3K/AKT and also through AMPK pathway in the skeletal muscle and it can also improve skeletal muscle oxidative metabolism through the NAD-dependent deacetylase (SIRT1)-PPAR pathway and also through improving fatty acid peroxidation ( In fact, overwhelming evidence summarized in this review supports the beneficial effects of Moringa oleifera in improving blood glucose levels, lipid profiles and insulin sensitivity, in addition to protecting against hepatic or nephrotic damage in preclinical (animal) models of T1D/T2D (Table 1 and 2)