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64 , 65 In murine MM models, inhibiting HIF1 downregulated proangiogenic genes, including vascular endothelial growth factor, and led to a reduction in the weight and volume of the tumor burden

48 Noteworthy, several analytical techniques are applicable for characterizing the modified drug/CD complexes in the solid state, including thermo-analytical techniques (Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Hot-stage microscopy (HSM)), X-ray diffraction (Single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD)), Spectroscopic techniques (Fourier-transform infra-red (FT-IR) spectroscopy, Attenuated total reflectance (ATR)-FTIR spectroscopy, and Raman spectroscopy), and Scanning electron microscopy (SEM)