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Smith JJ , Feo L, Garcia-Aguilar J

Figure 2 Glutathione Metabolic Pathway The activity of lipid repair enzyme called GPX4 which exerts an antioxidative effect on ferroptotic process depends on the biosynthesis of glutathione (GSH) ( Lipid Peroxidation Pathway Researchers have discovered that ferroptosis is preferentially accompanies by lipid peroxidation including polyphosphorylated phosphatidylethanolamine (PE) containing polyunsaturated fatty acids (PUFAs) ( NADPH-FSP1-CoQ10 Pathway It has been demonstrated by Doll and colleagues that overexpression of apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also named as FSP1) ( 10 antioxidant system ( Iron Metabolism Pathway Both process and development of ferroptosis relies on overload iron that ascribe to peroxides and divalent ferrous salts produced by fenton reaction

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10.1016/j.jhazmat.2022.129862* 22 LiangW.MenkeA

One multicenter, randomized, double-blind, placebo-controlled study has examined the efficacy of curcumin enema (2 g/day) in the prevention of relapse in 82 patients with quiescent UC (88)