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Discoid Lupus Erythematosus (DLE) Discoid lupus mainly affects the skin, resulting in inflamed sores and scars

There, albumin-bound bilirubin is able to pass through the fenestrations and, via an active transport process in the hepatocyte membrane (binding to glutathione S-transferase , aka ligandin), moves to the endoplasmic reticulum, where it undergoes conjugation

Conversely, SARS-CoV-2 infection may exacerbate pre-existing conditions, leading to more severe COVID-19 outcome [27]

Takahara et al., 2014)

Gene-editing technology, from macromolecule therapeutics to organ transplantation: applications, limitations, and prospective uses

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