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The neuropathology of manganese-induced Parkinsonism
doi: 10.1210/en.2014-1671 92 LeWWBerghornKARassnickSHoffmanGE
The M1 and M2 are in fact two extremes of a still not completely known spectrum of macrophage activation states [109,111,112]
In practical terms, sericin can be delivered as an oral supplement as a protein isolate or silk protein powder to leverage its systemic effects
However, there are few data on NRF2 activation in microglia in human tissues or animal models of ALS, and NRF2 signaling has not yet been evaluated in oligodendrocytes, although this may be relevant in the case of ALS which also involves demyelination [316]
DEGseq: an R package for identifying differentially expressed genes from RNA-seq data
