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Simeons introduced the hCG diet in a 1954 medical journal article

Serum folate reflects short-term changes in diet and may be altered by recent meals, so fasting for about six hours beforehand is required, and repeated testing is needed to identify true deficiency

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Participants, with a mean age of 61 years, were randomly assigned to receive twice-weekly injections of either 50 mg of methylcobalamin or a placebo for 16 weeks (about four months)

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