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Description
They may damage important biomolecules, including lipids, proteins, and DNA (Lobo et al., 2010)
Together with the osmotic pressure created by cilia-tethered mucins and the apical epithelial membrane (about 180 Pa), this pressure steadily draws water from the underlying epithelial cells into the airway lining fluid, supporting the replacement of water lost through evaporation as the airways humidify inhaled air 1
But it will be recognized by the immune system in excess, activating the Toll-like receptor 4 (TLR 4) signaling pathway, and promoting the release of immune cells to release a large number of pro-inflammatory cytokines, such as TNF- and IL-6 (Qu et al., 2023)

Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic 7nAchR/JAK2/STAT3/NF-B pathway in rats exposed to chronic unpredictable mild stress

A 2009 paper in the Journal of Pharmacology and Experimental Therapeutics characterised that ipamorelin restored gastric motility in a rodent postoperative-ileus model (PMID 19289567)

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