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3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter

Contemporary reviews and consensus analyses indicate that exercise remains the most consistent and robust intervention for improving metabolic, musculoskeletal, and cardiometabolic outcomes across populations with obesity, whereas vitamin D supplementation shows clear benefit primarily in the context of deficiency (187)

Corral, Dan Li, Elizabeth A

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However, considering their beneficial effect on several CVD risk variables, more research into how these medications affect the onset and progression of CVD is essential

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