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GM fermented indigestible carbohydrates can prevent obesity through two different mechanisms

Moreover, lycopene administration decreased the levels of malonilaldehyde, a measure of membrane lipid peroxidation, increased the levels of GSH by 75.35% and the level of superoxyde dismutase (SOD) by 12% when compared to control

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To ask whether other -KG-producing enzymes regulate the YBX1AMPK axis similarly to GDH1, we further knocked down GPT2 and/or GOT2 in Huh7 and H1299 cells and found that GPT2 and GOT2 single or double depletion minimally impacted YBX1 and AMPK expression and intracellular -KG abundance (Supplementary Fig

From preclinical evidence to human studies: what makes a drug candidate ready for a First-in-Human trial