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At the regulatory level, aberrant activation of canonical pro-inflammatory pathways such as NF-B disrupts junctional complexes and induces cytokines, including IL-1, thereby amplifying inflammation and further compromising barrier integritya self-perpetuating cycle (Zeng et al., 2024)

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Biomed Pharma 99:664670 Boskabady MH, Farkhondeh T (2016) Antiinflammatory, antioxidant, and immunomodulatory effects of Crocus sativus L

SETD7, a lysine monomethylase, directly interacts with ubiquitin thioesterase 1 (OTUB1) to catalyse OTUB1 methylation at Lys 122, disrupting the interaction between OTUB1 and the anti-ferroptosis protein ubiquitin conjugating enzyme E2 N (UBE2N/UBC13) in H1299 lung cancer cells 59