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Today, drugs are known with proven efficacy for the prevention of major cardiovascular and cerebrovascular events: antiplatelets, ACE inhibitors, and lipid-lowering drugs (mainly statins, which additionally have a proven benefit for walking distance) [48]

Pharmacol Ther 111:949973 [DOI] [PubMed] [Google Scholar] Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C 2007 Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms

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