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10.1371/journal.pone.0034772 PLoS One

These data suggest that dihexa may have therapeutic potential as a treatment of disorders, such as Alzheimers disease, where augmented synaptic connectivity may be beneficial

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The logic is real but indirect: NAD+ falls with age, sirtuins depend on it, and propping up NAD+ is a recurring theme across the longevity peptides and compounds people study

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk