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This can happen if you suffer from various gastrointestinal issues including celiac disease, Crohns disease, cancer, damage to your digestive tract, or an infection

190 In one trial involving patients with pernicious anemia, a condition caused by B 12 malabsorption, 1,000 mcg of oral cyanocobalamin daily for one month corrected B 12 levels in 23 of the 26 participants

S2CID 2453114

For example, mutations in the SNCA, LRRK2 , and GBA genes have been shown to increase the risk of Parkinson's disease

doi: 10.1016/j.molmet.2017.02.002