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Tesamorelin is not recommended for use in pregnancy or breastfeeding due to the risk of fetal harm and potential HIV transmission, and is not indicated for modifying normal metabolic changes or visceral adipose tissue increases during pregnancy

These tolerability differences matter for long-term adherence

Compounds were flushed with argon before being stored in the dark at 20C using an automated storage system (A3-RTS store from Brooks) and their chemical integrity was controlled regularly by RP-HPLC, coupled to ESI-MS with UV and CAD detectors (Thermo)

(B) MB, TB, and NR increased oxygen consumption as compared to vehicle control

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Ethics declarations Conflict of interest All the authors agree with the content of the article and declare no conflict of interest (personal, academic or financial) associated with this study