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Phase 3: the REDEFINE trials The Phase 3 programme for CagriSema is conducted under the name REDEFINE a series of large, randomised, controlled trials designed to confirm efficacy and establish the safety profile required for regulatory approval

Oxidation primarily occurred at methionine residues Detected as a mass shift (+16 Da) in peptide fragments Indicates susceptibility of GLP-1 peptides to oxidative environments 2

Copper peptides, specifically GHK-Cu, work differently

Tannock I, 2013, 'From trial to practice: The Princess Margaret Hospital (PMH) experience with docetaxel and prednisone for men with metastatic castration resistant prostate cancer (mCRPC)', in JOURNAL OF CLINICAL ONCOLOGY , AMER SOC CLINICAL ONCOLOGY, FL, Orlando, presented at Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of American-Society-of-Clinical-Oncology (ASCO), FL, Orlando, 14 February 2013 - 16 February 2013, Conference Papers | 2012 Brade AM

Over the past decade, peptides have been widely applied in drug development