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Microbial-derived peptides and polysaccharides promote the expansion of intestinal regulatory T cells (Tregs) and their production of anti-inflammatory IL-10, whereas segmented filamentous bacteria (SFB) drive Th (T helper) 17 differentiation and their production of proinflammatory IL-17 [40, 41]

In Alzheimers disease, the production of pro-inflammatory factors and A can over-activate microglia, secrete inflammatory factors and neurotoxins, and then induce neuronal damage and even apoptosis, thereby triggering Alzheimers disease

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