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Description
Among the various compounds tested, PROTACs 62 (DC 50 = 0.11 M, D max = 87%) and 63 (DC 50 = 0.16 M, D max = 85%) stand out with the most robust in vitro cytotoxic effect against FaDu and resistant KM3/BTZ cell lines

Long-chain acylcarnitines were significantly lower in congenital hypothyroid patients (2.67 0.87 mol/L) compared to controls (3.15 0.93 mol/L
doi: 10.1128/jvi.72.5.3944-3951.1998

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Full-Pathway Inhibition: Whether the product can brighten across three dimensions: inhibiting tyrosinase, blocking melanin transport, and accelerating metabolism

The proposed mechanism is straightforward: glucocorticoids suppress GH secretion and directly inhibit osteoblasts
