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(PubMed) Desmond MA, Sobiecki JG, Jaworski M, et al

Aldehyde toxicity Aldehydes are very toxic substances, yet there is limited information about the symptoms for all but a few of the environmental aldehydes

GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

Excess vitamin B12 can result in the possibility of blood clots overly and unduly forming in important blood vessels

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express ion channels (eg, K ATP channels) and G-protein receptors (eg, prostaglandin E2 receptor 4, 1-adrenergic receptors, and adenosine 2A receptors) for vasoactive mediators