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Following single oral doses R , S -lipoic acid (racemic mixture), peak plasma concentrations of R -lipoic acid were found to be 40%-50% higher than S -lipoic acid, suggesting a differential absorption in favor of the R -enantiomer (6, 8, 11)

16 March 2005

Pollard and Pomfrett specifically noted no tolerance induction in their work, and the older European clinical data on chronic insomnia models doesnt describe tolerance development either

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In changing the frequency of the patients treatment regimens and we were conscious that we were disturbing what for many had become a regular part of their lives, often over many years

doi:10.1111/jfbc.13507