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Pfizer purchased exclusive global commercialization rights for the then-experimental treatment in December 2014 for $295 million upfront and a promise of up to $275 million in milestones

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Briefly, for seven weeks, the medium was replaced once a week with complete PC-1 medium with gradually decreasing serum concentration from 5%, 2.5%, 1.25%, 0.75%, 0.5%, 0.25% to 0%