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In spite of considerable efforts by industrial and academic laboratories, no major breakthrough in the effective oral delivery of polypeptides and proteins has been accomplished

Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Par PD: The nature of small-airway obstruction in chronic obstructive pulmonary disease

Overall, the results of these studies show that MECP2 gene expression is necessary for normal synaptic development, the balance between the excitatory and inhibitory neurotransmission, morphology, and density of dendritic spines in the brain

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Mild side effects may include nausea, bloating, headache, or stomach discomfort in some users