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Nordihydroguaiaretic acid (NDGA) exhibits proven senomorphic properties, extending life by 810% in male mice [129]

by nitrogen and/or sulphur deficiency

With this there will be a rise in age-related health conditions including but not limited to Alzheimers disease, cardiovascular, metabolic, cancer as well as other diseases that typically double in incidence after every 5 years after 60 years old (Melzer et al., 2020)

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Regulation of antioxidant system, lipids and fatty acid -oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats

Any stress to the sensitive systemic electrolyte balance during hyperthermic endurance result in performance-limiting experience and premature fatigue