glutathione antioxidant system and associated enzymes Glutathione: Master Antioxidant, Reducing Oxidative Stress, Detoxification Glutathione - an overview |

Starting from very low levels, even a BAC of 0.02% can cause an altered mood and slight judgment loss

The l-methionine vs sam-e pathway analysis demonstrates that SAM-e bypasses the rate-limiting steps and cofactor dependencies that can restrict L-methionines therapeutic effectiveness, particularly in individuals with genetic variations affecting methionine metabolism

That's in addition to, as mentioned by Gambit, excess alcohol causing issues with the liver which is the primary bodily store of B12

Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase

R., Jiang, Y

Indian J Gastroenterol 37(3):215225