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Further, we described that LDHB protects specifically KRAS-mutant lung cancer cells from ferroptosis, mainly of the plasma membrane, by maintaining SLC7A11-mediated glutathione metabolism 24

This actually happening tripeptide, composed of glutamine, cysteine, and glycine, is included in various organic forms that bolster cellular steadiness and detoxification

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Luthman M, Holmgren A

However, although our genetically engineered mouse model of RMC reproduces the aggressive and metastatic phenotypes observed clinically, there is no perfect equivalence between mouse models and human diseases, and thus, caution must be exercised when extrapolating these findings to the clinic