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183,189,190 Senescent fibroblasts secrete matrix metalloproteinase 3, which affects the morphological and functional differentiation of mammary epithelial cells, ultimately relaxing restrictions on cell migration/invasion

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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Nordvall G., Forsell P., Sandin J

Humans have less GST activity or 8,9-epoxide conjugation than rats or mice suggesting that humans are less capable of detoxifying this important metabolite [48]

These findings suggest that curcumin may exert chemopreventive effects in CRC by modulating the expression of specific miRNAs, leading to the suppression of oncogenic pathways
