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Shift workers and frequent travelers Circadian rhythm disruption from rotating shifts or frequent time zone changes creates a specific type of sleep problem that melatonin alone handles poorly

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GSOR is then cleaved into GSSG and ROH by a second nucleophilic substitution by the GSH molecule according to a mechanism that is not yet fully elucidated ( 2 to 10 4 M -1 s -1 ) measured in steady-state conditions in the range of those of TRX- and GRX-dependent thiol peroxidases ( 7 s -1 for some thiol peroxidases

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10.1152/physiolgenomics.00028.2019 [DOI] [PMC free article] [PubMed] [Google Scholar] 44.Wahli W, Michalik L