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The contribution of oxidative stress to necroptosis appears to be highly context-dependent

Cancer: Since glutathione helps protect DNA from damage, low levels may allow genetic mutations to occur more frequently potentially increasing cancer risk

R.Fink-GremmelsJ.RoelenB

RFBP has 9 disulfides (and consequently 33 million disulfide isomers for the fully oxidized protein)

Each iron complex was incubated in water with GSH or GSSG in the ratio 1:1 for 1, 3 and 5 min

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