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it is estimated that melatonin may scavenge as many as 10 radical species via this pathway ( 2 - (Figures 4, 6) ( and IL-1 which activate immune cells leading to the creation of damaging oxygen-based and nitrogen-based reactants (210)

Liu J, Shen JX, Wen XF, Guo YX, Zhang GJ

Permanent activation of Nrf2 by the genetic knockout of its negative regulator KEAP1 is extremely unfavorable for the organism: newborn knockout mice die quickly from starvation, most likely due to increased expression of -keratins and subsequent gastrointestinal keratosis [88]

Exogenous MT triggers the endogenous MT biosynthetic activity by up-regulating the expression of MT-biosynthetic genes (Ni et al

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