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Activation of genes encoding antioxidant enzymes such as catalases and GST1 was detected in the tissue surrounding the initial infection site (Schenk et al., 2000)

Additionally, -Ketoglutarate(-KG) inhibited ferroptosis, significantly reducing matrix degradation and apoptosis in chondrocytes via the ETV4/SLC7A11/GPX4 signaling pathway, showing future clinical application prospects (He R

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26 The compound has been available in clinical practice for several decades to treat various medical conditions, including bronchitis, acute respiratory distress syndrome, paracetamol intoxication, chemotherapy-related toxicity, doxorubicin cardiotoxicity, heavy metal intoxication, ischemia-reperfusion cardiac injury, human immunodeficiency virus infection or acquired immunodeficiency syndrome, and neuropsychiatric disorders

G., Wang, Z., Schey, K

GSTs expressed ubiquitously, but tissue-specific distribution is probably an adaptive response against endo- and exogenous metabolites [196]