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In FOXO4-DRI (D-retro-inverso-isoform peptide), L-amino acids are substituted by D-amino acids that mimic the FOXO4 p53 binding domain
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A recent phase 2 trial investigating the triple-hormone-receptor agonist Retatrutide (LY3437943), targeting GLP-1R/GIPR/GCGR, yielded impressive results

Intestinal inflammation can trigger systemic and central inflammatory responses

Recently, cuproptosis has been identified as a primary mechanism promoting Cu-mediated cell death in tumor cells treated with the Cu ionophore elesclomol 5

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