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6.10 Anti-hyperglycemic activity Diabetes mellitus (DM) is a life-changing metabolic condition caused by abnormal insulin production, receptor activation, or both (Kharroubi and Darwish, 2015)

Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

Front Pharmacol 9:1181 Gao Y, Li J, Wu L, Zhou C, Wang Q, Li X, Zhou M, Wang H (2016) Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism

doi: 10.1016/j.pain.2009.07.018

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