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The timeline below tracks the drug from first dose through full clearance

The quantitative analysis of the area under the curve (AUC) (Fig

Cystine-free/GSH-supplemented = 6

In contrast, treatments that increase the expression of GCLC alone such as insulin, hydrocortisone in cultured hepatocytes and ethanol feeding in vivo , had no influence on GS expression

Jayaraman et al., 2021

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