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The study recruited participants through endometriosis advocacy platforms, social media, and clinical networks, targeting women aged 18 to 55 with confirmed or suspected endometriosis and current or prior GLP-1 medication use

Centrally, without therapy, in the isoprenaline rats, there was intracranial (superior sagittal sinus) hypertension, severe brain swelling, large intracerebral hemorrhage, and intraventricular hemorrhage in the third ventricle, marked karyopyknosis in the cerebral, cerebellar cortex and hippocampus, while the hypothalamus appeared to be relatively spared (only rare karyopyknotic cells) [38]

Translational Data The Morris Water Maze is a principal task in behavioral investigations and can also be extended to studies involving the understanding of cerebral functions and in the development of potential treatments

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As mentioned before, phosphorylated USP20 deubiquitinates 1 -AR and inhibits their lysosomal degradation but promotes ubiquitination and lysosomal degradation of the 2 -AR (Bristow et al., 1982