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Thymosin Alpha-1, for example, has a plasma half-life of approximately 2 hours but exerts immunomodulatory effects for considerably longer periods, likely because of downstream signaling cascades that persist well beyond peptide clearance

doi: 10.3389/fnmol.2021.714768

Blood 115, 27692776 (2010)
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Hum Neurobiol 4:9195 Braak H, Braak E (1976) The pyramidal cells of Betz within the cingulate and precentral gigantopyramidal field in the human brain

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