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We found that the PhenoAge age gap was significantly correlated with multiple organ age gaps, but only a small portion of the variance in any model was explained by another (Extended Data Fig

Although we are unable to directly assess site-specific LepR ICD phosphorylation with available reagents, these results indicate that phosphorylation of Tyr1141 may occur more efficiently than phosphorylation of Tyr986, such that reducing stability of the 2:2 complex more substantially impacts phosphorylation at Tyr986

This novel mode of cell death involves the interaction of copper with lipoacylated proteins within the tricarboxylic acid cycle, leading to proteinotoxic stress and culminating in cell death

Colombo et al

Martnez Centro de Investigacin y Enseanza Avcola, Departamento de Ciencia y Produccin Agropecuaria, Escuela Agrcola Panamericana