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Increased flux of key cellular energy regulators, including NAD + and SAM, may potentially define the therapeutic mechanism-of-action of NNMT inhibitors

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A compound that restores adipocyte metabolism without suppressing appetite could theoretically produce fat-specific weight loss that preserves lean mass a highly desirable outcome

Skeletal muscle ageing models preclinical investigation has explored NNMT inhibition in models of age-related muscle dysfunction and stem-cell quiescence