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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

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In this context, the animals were divided into three groups that received the peptide (10 mg and 10 ng/kg b.w

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

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It leads to anemia, fatigue , and other issues