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Insulin negatively regulates MTTP mRNA in an acute, dose-dependent fashion, which was elucidated in cultured HepG2 cells (195)

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L-2-HGA-associated genetic variants inhibit the activity of L-2hydroxyglutaric acid dehydrogenase (L2HGDH), an important mitochondrial enzyme involved in the metabolic processes of glutamate and glutamine, which oxidizes the L-2-hydroxyglutarate into -ketoglutarate [46] (Fig

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